Tuesday, 24 March 2015

Paracetamol Manufacturing Techniques

Paracetamol is a low-priced and most commonly used analgesic and antipyretic agent. In the manufacturing process of Paracetamol four different techniques have been used such as Phenol method, Para Nitrochloro Benzene method, Nitrobenzene method and Para Hydroxyacetophenone Hydrazine Route. The whole world market for Paracetamol bulk drug is expected to be around 1,10,000 tonnes per annum. North America and Europe is accounting for almost 40% of the total market.

India, USA, Turkey, Germany and China are the top producers of Paracetamol bulk drug. However, top Paracetamol bulk drug manufacturers are in USA. In India, manufacturing of Paracetamol was initiated in late 1960’s.  The total consumption of Paracetamol till 1970 was about 700-800 tonnes per annum as during this time Analgin and Aspirin were commonly used antipyretic and analgesic agents.


Paracetamolbulk drug manufacturers are convinced that the quality of Paracetamol manufactured by them should match global standards. Thereby, as far as quality is concerned, they do not face any issues in exporting the Paracetamol products. Pharma manufacturers in India are looking for potential partners with advanced and innovative technologies to match changing demands of global consumers. Pharma Industry has paid proper attention and taken right steps to improve safety standard in the manufacturing plants. Leading pharma companies organize training programmes and seminars to spread awareness about important safely aspects.


Top pharma companies have realized that quality assurance and GMP procedures don’t cost much, thus they consider it as their mission to train manpower about GMP needs. They provided their manpower with the required infrastructure and manufacturing facilities to improve overall quality of end products.

Know about Paracetamol Bulk Drug Manufacturers

Paracetamol falls under the category of medicines which is known as analgesics, mostly used to get relive from fever (hot temperature) and different types of aches. Paracetamol is easily accessible in all retail medicine shops. It is manufactured in the form of syrups, capsules, tablets, suspensions and injectables. It is also available in the form of powder available in sachets.

There are various companies which are involved in manufacturing and supplying of paracetamol medicines. Leading paracetamol bulk drug manufacturers and suppliers realize the requirements of patients and thus, provide the paracetamol tablets produced from using hi-tech drug processing machines and premium grade.


Paracetamolbulk drug manufacturers are contributing to improve the quality of human health by manufacturing first class drugs in different types. They have manufacturing team who has expertise in most dosage forms including sterilized as well as non sterilized products.  Paracetamol drugs are tested as per standard quality parameters to make certain that only high quality drugs are delivered at clients’ location within the decided time limit. Bulk drugs manufactured by foremost drug companies are widely utilized in health care and pharmaceutical sector.


Manufacturers, who are engaged in bulk drug manufacturing driven with a passion to innovate, develop and upgrade its tools and techniques to improve the quality of end products. A laboratory well equipped by sophisticated tools and machineries, manned by technicians and researchers enable the pharma firm to improve proficiency and techniques of manufacturing. Researchers convey the huge amount of new services every year.

Paracetamol Bulk Drug Manufacturing Process

Owing to technologically advanced manufacturing infrastructure, leading pharma companies are producing wide array of bulk drugs.  A bulk drug is also known as API (Active Pharmaceutical Ingredient) which is the chemical particle in a pharmaceutical product and provides the therapeutic effect in a medicine. Paracetamol bulk drug is manufactured by many pharma companies as it is highly demanded in the market.

If the bulk drug is missing, the product is no longer a drug and when it is altered, it is a different medicine. In most of the accessible bulk drugs, change of inactive ingredients does not impact the healing efficiency of the product, even though exceptions are always there. Thereby, the drug manufacturers relatively have the freedom to "formulate" the bulk drug by using excipents of their selection depending on chemical viability and profitable interests.


The drugs present in the form of capsules, tablets, syrups, powders, drops, intravenous fluids etc., available in the market are hence "formulations." In Simple words, the products referred as medicines are formulations of bulk drugs and not bulk drugs as such. Launching a new bulk drug whether it is paracetamol bulk drug or any other is quite expensive proposition which also needs thorough scientific research, huge risks of expensive failures and legalization trials.

Some MNCs states they invest $800m for a new medicine invention. A new drug request is being filed before a controller when an agency wishes to introduce a new chemical product, bulk drug with a high therapeutic effect.